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Allergies: the molecular revolution is underway
29 janvier 2026
By Ana Espino | Published on January 29, 2026 | 3 min readAllergic diseases affect approximately 30 to 40% of the global population, with an increasing prevalence. They are caused by an inappropriate IgE-mediated immune response to normally harmless allergens, leading to clinical manifestations ranging from rhinitis to anaphylaxis. Management currently relies on allergen avoidance, symptomatic tre
By Ana Espino | Published on January 29, 2026 | 3 min read
Allergic diseases affect approximately 30 to 40% of the global population, with an increasing prevalence. They are caused by an inappropriate IgE-mediated immune response to normally harmless allergens, leading to clinical manifestations ranging from rhinitis to anaphylaxis.
Management currently relies on allergen avoidance, symptomatic treatments (antihistamines, corticosteroids), and, in some cases, allergen-specific immunotherapy (AIT). However, conventional diagnosis, based on skin prick tests and the measurement of specific IgE to allergen extracts, lacks precision. These tests fail to differentiate between cross-reactivity and clinically relevant sensitizations, which limits the ability to personalize treatment.
Allergic diseases affect approximately 30 to 40% of the global population, with an increasing prevalence. They are caused by an inappropriate IgE-mediated immune response to normally harmless allergens, leading to clinical manifestations ranging from rhinitis to anaphylaxis.
Management currently relies on allergen avoidance, symptomatic treatments (antihistamines, corticosteroids), and, in some cases, allergen-specific immunotherapy (AIT). However, conventional diagnosis, based on skin prick tests and the measurement of specific IgE to allergen extracts, lacks precision. These tests fail to differentiate between cross-reactivity and clinically relevant sensitizations, which limits the ability to personalize treatment.
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Scientific reference
Matricardi PM, et al. Molecular allergy diagnosis enabling personalized medicine. J Allergy Clin Immunol. 2025 Sep;156(3):485-502
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