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CBD & Sun: innovation beneath the skin
15 mai 2025
#UV #Sunscreen #Oncology #Cannabidiol #nCBD
UV-A radiation is a major contributor to skin photoaging and photocarcinogenesis due to its ability to penetrate deep into the dermis. Unlike UV-B rays, which cause visible sunburn, UV-A rays produce large amounts of reactive oxygen species (ROS), leading to persistent damage to both nuclear and mitochondrial DNA, as well as chronic inflammation. Among the most common alterations are 8-oxoguanine base oxidation and mitochondrial DNA deletions such as ND1 and ND4. These lesions are directly linked to accelerated skin aging and an increased risk of skin cancer.
UV-A radiation is a major contributor to skin photoaging and photocarcinogenesis due to its ability to penetrate deep into the dermis. Unlike UV-B rays, which cause visible sunburn, UV-A rays produce large amounts of reactive oxygen species (ROS), leading to persistent damage to both nuclear and mitochondrial DNA, as well as chronic inflammation. Among the most common alterations are 8-oxoguanine base oxidation and mitochondrial DNA deletions such as ND1 and ND4. These lesions are directly linked to accelerated skin aging and an increased risk of skin cancer.
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Scientific reference
McCormick, E. et al. (2024) Topical nanoencapsulated cannabidiol cream as an innovative strategy combating UV-A-induced nuclear and mitochondrial DNA injury: A pilot randomized clinical study. Journal of the American Academy of Dermatology, 91(5), 855–862
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