Efficacy and safety of upadacitinib in the treatment of moderate to severe atopic dermatitis in adolescents: a systematic review and meta-analysis of randomised controlled trials

A comprehensive search was conducted using PubMed, Medline, Embase, Web of Science, Clinical Trials Website and Cochrane Library databases from inception to 18 February 2024. The review included all randomised controlled trials examining the efficacy of upadacitinib in the management of moderate to severe atopic dermatitis in adolescent patients. The methodological quality of the selected studies was thoroughly assessed using the Cochrane systematic review methodology.