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What if intracellular microbes promote metastasis in breast cancer?
31 octobre 2025
By Lila Rouland | Published on October 31, 2025 | 3 min readBreast cancer, the leading cause of cancer-related death among women worldwide, is particularly feared for its ability to spread and form metastases. While tumor and immune factors involved in this process are well established, the role of the tumor microbiome, especially intracellular bacteria, remains largely unexplored. Bacteria have b
By Lila Rouland | Published on October 31, 2025 | 3 min read
Breast cancer, the leading cause of cancer-related death among women worldwide, is particularly feared for its ability to spread and form metastases. While tumor and immune factors involved in this process are well established, the role of the tumor microbiome, especially intracellular bacteria, remains largely unexplored.
Bacteria have been detected within human tumors, including inside cancer cells themselves. This surprising finding raises a fundamental question: could these intracellular microbes influence metastatic colonization?
Breast cancer, the leading cause of cancer-related death among women worldwide, is particularly feared for its ability to spread and form metastases. While tumor and immune factors involved in this process are well established, the role of the tumor microbiome, especially intracellular bacteria, remains largely unexplored.
Bacteria have been detected within human tumors, including inside cancer cells themselves. This surprising finding raises a fundamental question: could these intracellular microbes influence metastatic colonization?
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Scientific reference
Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer. Cell. 2022;185(8):1356-1372.e26. doi: 10.1016/j.cell.2022.03.027.
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