Colorectal cancer-related fatigue: can the mind make a difference?

By Ana Espino | Published on March 31, 2026 | 3 min read


Colorectal cancer (CRC) is among the most common cancers worldwide. Despite therapeutic advances, a large proportion of patients develop cancer-related fatigue (CRF), a multidimensional symptom affecting physical, emotional, and cognitive functioning. This fatigue often persists after treatment and significantly impacts quality of life and survival.  

Pharmacological treatments remain limited and are associated with adverse effects. Non-pharmacological approaches, such as physical activity, may face adherence challenges. In this context, psychosocial interventions are emerging as a promising alternative, targeting behaviors, emotions, and coping mechanisms.  

This systematic review and meta-analysis of randomized controlled trials, published in 2026 in Supportive Care in Cancer, aimed to evaluate the effectiveness of these interventions on CRF in patients with CRC, as well as their effects on anxiety and depression.