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Early fibrinogen: a lifesaving drip?
6 août 2025
By Ana Espino | Published on August 06, 2025 | 2 min read
#Fibrinogen #Hemorrhage #Coagulopathy
Traumatic hemorrhage is a leading cause of preventable death in patients suffering from severe trauma, particularly in the first few hours after injury. It is often worsened by acute coagulopathy, which arises within minutes of the trauma and contributes to increased bleeding. Among the early abnormalities observed, fibrinogen deficiency is one of the first factors to be altered and is a key determinant of clot stability.
#Fibrinogen #Hemorrhage #Coagulopathy
Traumatic hemorrhage is a leading cause of preventable death in patients suffering from severe trauma, particularly in the first few hours after injury. It is often worsened by acute coagulopathy, which arises within minutes of the trauma and contributes to increased bleeding. Among the early abnormalities observed, fibrinogen deficiency is one of the first factors to be altered and is a key determinant of clot stability.
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Scientific reference
Burt, T., et al. (2025). Effect of early administration of fibrinogen replacement therapy in traumatic haemorrhage: a systematic review […] of randomised controlled trials with narrative synthesis of observational studies. Critical care (London) 29(1), 49
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