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Smoke less, think better?
2 juin 2025
#Nicotine #Tobacco #NAC #MET #Neuroplasticity
#SmokingCessation
Nicotine addiction is now recognized as a chronic behavioral disorder with both psychological and neurobiological underpinnings. It is driven by powerful positive reinforcement, orchestrated by complex neurochemical cascades primarily involving the dopaminergic and glutamatergic systems. Nicotine stimulates dopamine release in the nucleus accumbens, generating a rewarding sensation, while glutamate modulates circuits related to reinforcement, pleasure memory, and compulsive behavior.
Nicotine addiction is now recognized as a chronic behavioral disorder with both psychological and neurobiological underpinnings. It is driven by powerful positive reinforcement, orchestrated by complex neurochemical cascades primarily involving the dopaminergic and glutamatergic systems. Nicotine stimulates dopamine release in the nucleus accumbens, generating a rewarding sensation, while glutamate modulates circuits related to reinforcement, pleasure memory, and compulsive behavior.
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Scientific reference
Nasrun, M. W., et al. (2025). Efficacy of N-acetylcysteine and motivational enhancement therapy for nicotine addiction: A randomized clinical trial. Narra J, 5(1), e2178
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