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Fats and Hormones: A Link to Clarify?
17 janvier 2025
The Insulin-like Growth Factor 1 (IGF-1) and its binding proteins (IGFBPs) play
a key role in regulating cellular growth, apoptosis, and metabolic homeostasis.
Imbalances in their concentrations have been associated with serious conditions
such as cancer, cardiovascular diseases, and metabolic disorders. Identifying
modifiable factors influencing these biomarkers could provide new perspectives
in prevention strategies.
Among potential determinants, the role of low-fat diets remains controversial. While some studies suggest a decrease in IGF-1 and IGFBPs levels with reduced fat intake, others have observed no effect or even increases. These inconsistencies highlight an urgent need for a comprehensive synthesis and global analysis of existing data. This study explores the impact of low-fat diets on IGF-1 and IGFBP concentrations.
Among potential determinants, the role of low-fat diets remains controversial. While some studies suggest a decrease in IGF-1 and IGFBPs levels with reduced fat intake, others have observed no effect or even increases. These inconsistencies highlight an urgent need for a comprehensive synthesis and global analysis of existing data. This study explores the impact of low-fat diets on IGF-1 and IGFBP concentrations.
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Scientific reference
Sangsefidi, Z. S., et a. (2024). Effectiveness of low-fat diet on the levels of insulin-like growth factor-1 and insulin-like growth factor binding proteins: a systematic review […]. Journal of health, population, and nutrition, 43(1), 201
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