This content is in French.
HER2, the key to revolutionizing cancer treatment
4 février 2025
#Oncology #Cancer #HER2 #TargetedTherapy #TherapeuticInnovation
HER2 (human epidermal growth factor receptor 2) is a transmembrane receptor involved in the regulation of cell growth and intracellular signaling. Its role is critical in several types of cancer, such as breast, gastric, bladder, and non-small cell lung cancer (NSCLC), where it is frequently altered. These alterations result from genetic mutations, HER2 gene amplifications, or overexpression on the surface of tumor cells. They lead to abnormal activation of signaling pathways, promoting uncontrolled cell proliferation, tumor cell survival, and resistance to conventional treatments.
HER2 (human epidermal growth factor receptor 2) is a transmembrane receptor involved in the regulation of cell growth and intracellular signaling. Its role is critical in several types of cancer, such as breast, gastric, bladder, and non-small cell lung cancer (NSCLC), where it is frequently altered. These alterations result from genetic mutations, HER2 gene amplifications, or overexpression on the surface of tumor cells. They lead to abnormal activation of signaling pathways, promoting uncontrolled cell proliferation, tumor cell survival, and resistance to conventional treatments.
Sign in to read the rest
Reserved for healthcare professionals, free registration.
Scientific reference
Zhu, K., et al. (2024). HER2-targeted therapies in cancer: a systematic review. Biomarker Research, 12(1), 16
View the source
