Homocysteine and mortality in sepsis: a promising predictive biomarker?

Sepsis is an acute inflammatory response to infection, often associated with high mortality despite advances in intensive care. Identifying reliable predictive biomarkers is therefore essential to improve patient management and reduce mortality. Among the biomarkers explored, homocysteine (Hcy) appears to be a potential indicator, due to its role in oxidative stress, endothelial dysfunction and inflammation, essential mechanisms in the pathophysiology of sepsis. This study explores the association between Hcy levels and short-term mortality in patients with sepsis.