Memory Immunity Against COVID-19: A Less Effective Response in Organ Transplant Recipients?

Vaccination against COVID-19 has transformed the fight against the pandemic. However, the immune response to vaccination is not uniform across all individuals. Solid organ transplant recipients are among the high-risk groups for severe COVID-19 due to their weakened immune systems, compromised by immunosuppressive medications required to prevent graft rejection. This study examines the role of SARS-CoV-2-specific memory B cells in post-vaccination immunity, assessing their capacity to induce a protective response in this vulnerable population.