Inflammation: When Childhood Trauma Leads to Depression

Adverse childhood experiences (ACEs) are well-established risk factors for the development of depressive disorders in adulthood. Early trauma disrupts psychobiological and physiological mechanisms, increasing vulnerability to mental health issues later in life. Recent research highlights the central role of inflammation as a biological response to stress and trauma in the pathophysiology of depression. Prolonged inflammation may induce changes in the brain that influence mood and behavior. This study investigates the mediating role of inflammation in the relationship between ACEs and depression.