Gut microbiota is involved in the progression of non-alcoholic fatty liver disease

10 mai 2024

Non-alcoholic fatty liver disease (NAFLD) is characterized by an accumulation of fat in the liver, irrespective of excessive alcohol consumption. The advanced stage of this disease is called non-alcoholic steatohepatitis (NASH).In this study, changes in the gut microbiota associated with progression from NAFLD to NASH were analyzed with the aim of better understanding the differences between the m

In this study, changes in the gut microbiota associated with progression from NAFLD to NASH were analyzed with the aim of better understanding the differences between the microbiota of patients with NAFLD and NASH.

Gut microbiota composition was compared in three groups, healthy controls, NAFLD patients and NASH patients. It was collected using the rRNA sequencing technique on participants recruited from the Shenzhen Traditional Chinese Medicine Hospital who provided stool samples.

A significant decrease in the diversity of intestinal flora was observed in patients with NAFLD and NASH, with a higher abundance of "Bacteroidetes" and "Fusobacteria". Conversely, a lower abundance of "Firmicutes" was found in these patients.

A significant decrease in "Prevotella" was observed in NAFLD patients, while an increase in "Megamonas" and "Fusobacterium" was noted in NASH patients.

This study highlights the important changes in gut microbiota composition in the progression from NAFLD to NASH. It proposes solutions that could facilitate the discovery of new biomarkers and therapeutic targets to combat NAFLD.

In conclusion, the authors of this study suggest that microbiome-based interventions could be developed to prevent or treat this disease non-invasively.

Reserved for healthcare professionals, free registration.

Scientific reference

Huang, F., Lyu, B., Xie, F., Li, F., Xing, Y., Han, Z., Lai, J., Ma, J., Zou, Y., Zeng, H., Xu, Z., Gao, P., Luo, Y., Bolund, L., Tong, G., & Fengping, X. (2024). From gut to liver: unveiling the differences of intestinal microbiota in NAFL and NASH patie

Voir la source

Autres articles récents

Does Nicotinamide Really Prevent Skin Cancer?

1 juillet 2026

Exercising in Extreme Heat: How Can Performance Be Preserved While Reducing Health Risks?

29 juin 2026

Oropouche Virus: A New Threat to Monitor During Pregnancy?

26 juin 2026

Toute la revue de presse