The Ketogenic Diet: A Recipe Against Depression?

Treatment-resistant depression (TRD) is a severe form of depression that persists despite the use of at least two adequate antidepressant treatments. This condition, affecting approximately one-third of depressed patients, represents a significant challenge in psychiatry. TRD is associated with significantly reduced quality of life, increased risk of comorbidities, including anxiety and cardiovascular diseases, and higher mortality rates.

Despite the benefits of current treatments, their effectiveness remains limited for these patients, highlighting an urgent need for alternative solutions. These new approaches must target biological mechanisms often overlooked by conventional treatments while offering innovative and personalized options.