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Is early therapeutic intensification the key to treating metastatic castration-sensitive prostate cancer?
13 novembre 2025
By Lila Rouland | Published on November 13, 2025 | 4 min readMetastatic castration-sensitive prostate cancer (mCSPC) remains a major public health challenge for men worldwide. Historically, its management relied on androgen deprivation therapy (ADT) alone. However, advances in understanding the androgen receptor (AR) signaling pathway have profoundly changed therapeutic strategies. The early integ
By Lila Rouland | Published on November 13, 2025 | 4 min read
Metastatic castration-sensitive prostate cancer (mCSPC) remains a major public health challenge for men worldwide. Historically, its management relied on androgen deprivation therapy (ADT) alone. However, advances in understanding the androgen receptor (AR) signaling pathway have profoundly changed therapeutic strategies. The early integration of chemotherapy (such as docetaxel) or androgen receptor signaling inhibitors (ARSi) has significantly improved overall survival, particularly in patients with high-volume disease. This review provides an updated overview of validated treatment strategies and emerging therapies.
Metastatic castration-sensitive prostate cancer (mCSPC) remains a major public health challenge for men worldwide. Historically, its management relied on androgen deprivation therapy (ADT) alone. However, advances in understanding the androgen receptor (AR) signaling pathway have profoundly changed therapeutic strategies. The early integration of chemotherapy (such as docetaxel) or androgen receptor signaling inhibitors (ARSi) has significantly improved overall survival, particularly in patients with high-volume disease. This review provides an updated overview of validated treatment strategies and emerging therapies.
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Scientific reference
Troy SP, Jakubowski CD, Gartrell BA. Packing the Punch: Current and Emerging Treatment Strategies in Metastatic Castration-Sensitive Prostate Cancer. Current Urology Reports. 2025;26:50.
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