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Cystic Fibrosis: could the microbiome change everything?
19 février 2025
#CysticFibrosis #Microbiome #InnovativeTherapies #Probiotics #LungInfections #PrecisionMedicine
Cystic fibrosis is a severe genetic disease caused by mutations in the CFTR gene, disrupting ion transport and leading to thick mucus accumulation in the airways. Despite advances with CFTR modulators, these treatments remain inaccessible to some patients and do not completely eliminate chronic infections or prevent lung damage.
Given these limitations, the respiratory microbiome is attracting growing interest. Recent studies suggest that altered microbial diversity in the lungs may encourage opportunistic pathogens and worsen disease progression. Exploring microbiome-based therapeutic approaches opens promising avenues to slow the progression of cystic fibrosis.
Cystic fibrosis is a severe genetic disease caused by mutations in the CFTR gene, disrupting ion transport and leading to thick mucus accumulation in the airways. Despite advances with CFTR modulators, these treatments remain inaccessible to some patients and do not completely eliminate chronic infections or prevent lung damage.
Given these limitations, the respiratory microbiome is attracting growing interest. Recent studies suggest that altered microbial diversity in the lungs may encourage opportunistic pathogens and worsen disease progression. Exploring microbiome-based therapeutic approaches opens promising avenues to slow the progression of cystic fibrosis.
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Scientific reference
Cauwenberghs, E., et al. (2024). Positioning the preventive potential of microbiome treatments for cystic fibrosis in the context of current therapies. Cell Reports Medicine, 5(1)
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