Neuromodulation for Neuropathic Pain: Which Techniques Offer the Greatest Relief?

New evidence highlights spinal cord stimulation as a promising option for neuropathic pain, while uncertainties remain about the effectiveness of other invasive and non-invasive approaches.

Neuropathic pain, caused by damage or disease affecting the somatosensory nervous system, affects approximately 7–10% of the population. First-line treatments include gabapentinoids, serotonin–noradrenaline reuptake inhibitors and tricyclic antidepressants. However, only around half of patients achieve meaningful pain relief, and adverse effects can limit treatment adherence.