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Polylaminin and the return of voluntary motor contraction after complete spinal cord injury: a landmark pilot study
9 mars 2026
By Carolina Lima | Published on March 9, 2026 | 3 min readAcute spinal cord injury (SCI) remains one of the most complex and devastating conditions in medicine. Even with advances in emergency care, neurosurgery and rehabilitation, motor recovery in patients with complete SCI (AIS A) is extremely uncommon. Historical data consistently show that fewer than 15% of these individuals recover any degre
Acute spinal cord injury (SCI) remains one of the most complex and devastating conditions in medicine. Even with advances in emergency care, neurosurgery and rehabilitation, motor recovery in patients with complete SCI (AIS A) is extremely uncommon. Historical data consistently show that fewer than 15% of these individuals recover any degree of voluntary muscle activation below the injury level. Against this background, a recent Brazilian pilot study evaluating polylaminin — a stabilized polymeric form of laminin — offers unexpected and clinically meaningful findings.
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Scientific reference
Menezes K, Lima MAB, Xerez DR, Menezes JRL, Holanda GS, Silva AD, et al. Return of voluntary motor contraction after complete spinal cord injury: a pilot human study on polylaminin. medRxiv [Preprint]. 2024. doi:10.1101/2024.02.19.24301010.
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