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Why Thalidomide Remains Unavoidable
23 janvier 2026
By Ana Espino | Published on January 23, 2026 | 3 min readLeprosy is a chronic infectious disease caused by Mycobacterium leprae, primarily affecting the skin and peripheral nerves. It is characterized by a clinical spectrum closely linked to the host immune response. Erythema nodosum leprosum (ENL) is one of the major complications of the disease. This type 2 inflammatory reaction, occurring in a
By Ana Espino | Published on January 23, 2026 | 3 min read
Leprosy is a chronic infectious disease caused by Mycobacterium leprae, primarily affecting the skin and peripheral nerves. It is characterized by a clinical spectrum closely linked to the host immune response. Erythema nodosum leprosum (ENL) is one of the major complications of the disease. This type 2 inflammatory reaction, occurring in approximately 50% of patients with lepromatous forms, represents a major cause of morbidity, responsible for severe pain, systemic involvement, and irreversible neurological damage.
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Scientific reference
Teo S, et al. Thalidomide in the treatment of leprosy. Microbes Infect. 2002 Sep;4(11):1193-202. doi: 10.1016/s1286-4579(02)01645-3. PMID: 12361920.
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