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When sleep apnea throws metabolism out of sync
6 mars 2026
By Elodie Vaz | Published on March 6, 2026 | 3 min readSleep apnea affects nearly one billion people worldwide. This condition is characterized by repeated interruptions of breathing during the night, leading to episodes of intermittent hypoxia. While the cardiovascular and metabolic consequences of this respiratory stress are well documented, its impact on the temporal organization of biological
By Elodie Vaz | Published on March 6, 2026 | 3 min read
Sleep apnea affects nearly one billion people worldwide. This condition is characterized by repeated interruptions of breathing during the night, leading to episodes of intermittent hypoxia. While the cardiovascular and metabolic consequences of this respiratory stress are well documented, its impact on the temporal organization of biological functions has remained largely unexplored.
A study published on February 25 in Science Advances by researchers from Université Grenoble Alpes, Inserm, and Grenoble Alpes University Hospital highlights a previously underappreciated dimension of the disease: intermittent hypoxia profoundly reorganizes the liver’s biological clock and alters the daily rhythms of its metabolic activity.
Sleep apnea affects nearly one billion people worldwide. This condition is characterized by repeated interruptions of breathing during the night, leading to episodes of intermittent hypoxia. While the cardiovascular and metabolic consequences of this respiratory stress are well documented, its impact on the temporal organization of biological functions has remained largely unexplored.
A study published on February 25 in Science Advances by researchers from Université Grenoble Alpes, Inserm, and Grenoble Alpes University Hospital highlights a previously underappreciated dimension of the disease: intermittent hypoxia profoundly reorganizes the liver’s biological clock and alters the daily rhythms of its metabolic activity.
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Scientific reference
Boufeldja L, et al. Intermittent hypoxia reprograms hepatic circadian metabolism. Science Advances. 2026; 12(aeb3756). doi:10.1126/sciadv.aeb3756
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