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When the gut challenges MS
28 mai 2025

#MultipleSclerosis #Microbiota #Immunity
#Probiotics
Multiple sclerosis (MS) is an autoimmune neurological disorder characterized by chronic inflammation of the central nervous system (CNS) and the progressive destruction of the myelin sheath surrounding nerve fibers. This demyelination hinders the conduction of nerve impulses, leading to motor, sensory, cognitive, and visual impairments. While the exact origins of the disease remain incompletely understood, scientific consensus increasingly points to the key role of immune dysregulation. In particular, abnormal lymphocyte activation, excessive production of pro-inflammatory cytokines, and oxidative stress are recognized as key drivers of the inflammatory response that leads to neurological damage.
Multiple sclerosis (MS) is an autoimmune neurological disorder characterized by chronic inflammation of the central nervous system (CNS) and the progressive destruction of the myelin sheath surrounding nerve fibers. This demyelination hinders the conduction of nerve impulses, leading to motor, sensory, cognitive, and visual impairments. While the exact origins of the disease remain incompletely understood, scientific consensus increasingly points to the key role of immune dysregulation. In particular, abnormal lymphocyte activation, excessive production of pro-inflammatory cytokines, and oxidative stress are recognized as key drivers of the inflammatory response that leads to neurological damage.
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Scientific reference
Zangeneh, Z., et al. (2025). The potential effectiveness of probiotics in reducing multiple sclerosis progression in preclinical and clinical studies: A worldwide systematic review and meta-analysis. PloS one, 20(4), e0319755
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