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Sepsis and memory: a link not to be forgotten!
27 février 2025
#Leukemia #ALL #AML #Infection #Sepsis #Neurocognition #Memory
Children diagnosed with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) are particularly vulnerable to infections due to aggressive treatments that weaken their immune systems. Chemotherapy and corticosteroids reduce natural defenses, while the use of central venous catheters increases the risk of bacterial and fungal infections.
Among these infections, severe sepsis is one of the most serious complications. This excessive inflammatory response to an infection can lead to multi-organ dysfunction, septic shock, and sometimes death. Beyond endangering patients’ lives, sepsis can also cause treatment interruptions, increasing the risk of relapse.
Children diagnosed with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) are particularly vulnerable to infections due to aggressive treatments that weaken their immune systems. Chemotherapy and corticosteroids reduce natural defenses, while the use of central venous catheters increases the risk of bacterial and fungal infections.
Among these infections, severe sepsis is one of the most serious complications. This excessive inflammatory response to an infection can lead to multi-organ dysfunction, septic shock, and sometimes death. Beyond endangering patients’ lives, sepsis can also cause treatment interruptions, increasing the risk of relapse.
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Scientific reference
Goggin, K. P., et al. (2024). Severe sepsis during treatment for childhood leukemia and Sequelae among adult Survivors. JAMA network open, 7(3), e242727-e242727
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