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PCOS: Is homocysteine the hidden fertility marker?
27 mai 2025
#PCOS #Fertility
#Homocysteine #Oocyte #Micronutrients #IVF #Methylation
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects approximately 20% of women of reproductive age. It is characterized by chronic hormonal imbalance, persistent anovulation, and polycystic ovarian morphology on ultrasound. Beyond its clinical manifestations, PCOS is currently one of the leading causes of female infertility worldwide.
Assessing fertility in this context remains a true clinical challenge. Despite medical advances, the identification of reliable biomarkers for oocyte quality is still lacking. Current approaches are often imprecise, poorly reproducible, and do not always reflect the potential for embryo development. This uncertainty is even greater in women with PCOS, whose follicular environment is profoundly altered metabolically, inflammatory-wise, and oxidatively.
Polycystic ovary syndrome (PCOS) is a complex endocrine disorder that affects approximately 20% of women of reproductive age. It is characterized by chronic hormonal imbalance, persistent anovulation, and polycystic ovarian morphology on ultrasound. Beyond its clinical manifestations, PCOS is currently one of the leading causes of female infertility worldwide.
Assessing fertility in this context remains a true clinical challenge. Despite medical advances, the identification of reliable biomarkers for oocyte quality is still lacking. Current approaches are often imprecise, poorly reproducible, and do not always reflect the potential for embryo development. This uncertainty is even greater in women with PCOS, whose follicular environment is profoundly altered metabolically, inflammatory-wise, and oxidatively.
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Scientific reference
Kucuk T. et al. Follicular homocysteine as a marker of oocyte quality in PCOS and the role of mi-cronutrients. Assist Reprod Genet. 2023 Aug;40(8):1933- 1941.
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