Testosterone replacement therapy with testosterone undecanoate

Testosterone replacement therapy can improve the consequences of testosterone deficiency in adults. But the treatments used could lead to high blood pressure. In this study, researchers evaluated the impact of testosterone undecanoate on blood pressure in 737 men with testosterone deficiency. This treatment was associated with significant reductions in systolic and diastolic blood pressure, as well as heart rate. These reductions were greater in the case of concomitant antihypertensive treatment. Only one patient started antihypertensive treatment during follow-up. On the other hand, 33 of the 202 men on antihypertensive medication at the start of the study were able to discontinue antihypertensive treatment during follow-up.