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TNBC and the microbiome: bacteria in the crosshairs
30 octobre 2025
By Ana Espino | Published on October 30, 2025 | 3 min readTriple-negative breast cancer (TNBC) is one of the most aggressive and heterogeneous forms of breast cancer. Lacking hormone receptors and HER2 overexpression, it escapes conventional targeted therapies, greatly limiting treatment options. Moreover, despite recent advances in immunotherapy, early relapse rates and mortality remain particula
By Ana Espino | Published on October 30, 2025 | 3 min read
Triple-negative breast cancer (TNBC) is one of the most aggressive and heterogeneous forms of breast cancer. Lacking hormone receptors and HER2 overexpression, it escapes conventional targeted therapies, greatly limiting treatment options. Moreover, despite recent advances in immunotherapy, early relapse rates and mortality remain particularly high.
In light of the aggressiveness of TNBC and the lack of therapeutic targets, the role of the tumor microbiome has attracted growing interest. Studies have revealed the presence of specific bacterial communities within breast tissue, capable of modulating the tumor microenvironment through immune, inflammatory, and metabolic mechanisms.
Triple-negative breast cancer (TNBC) is one of the most aggressive and heterogeneous forms of breast cancer. Lacking hormone receptors and HER2 overexpression, it escapes conventional targeted therapies, greatly limiting treatment options. Moreover, despite recent advances in immunotherapy, early relapse rates and mortality remain particularly high.
In light of the aggressiveness of TNBC and the lack of therapeutic targets, the role of the tumor microbiome has attracted growing interest. Studies have revealed the presence of specific bacterial communities within breast tissue, capable of modulating the tumor microenvironment through immune, inflammatory, and metabolic mechanisms.
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Scientific reference
Rashwan, H. H., et al. (2025). Unravelling novel microbial players in the breast tissue of TNBC patients: a meta-analytic perspective. NPJ biofilms and microbiomes, 11(1), 182
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