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Triple blow, triple clinical challenge
20 octobre 2025
By Ana Espino | Published on October 20, 2025 | 3 min readThe synchronous development of several primary cancers is a rare but increasingly observed phenomenon, particularly in patients carrying genetic mutations such as BRCA1. In this particular case, the coexistence of triple-negative breast cancer and rectal adenocarcinoma is all the more complex as it may occur in patients with chronic hepatit
The synchronous development of several primary cancers is a rare but increasingly observed phenomenon, particularly in patients carrying genetic mutations such as BRCA1. In this particular case, the coexistence of triple-negative breast cancer and rectal adenocarcinoma is all the more complex as it may occur in patients with chronic hepatitis B virus (HBV) infection.
This situation raises major therapeutic challenges. Chemotherapy and immunotherapy, which are essential for aggressive forms such as triple-negative breast cancer, can trigger severe viral reactivation, posing a significant life-threatening risk.
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Scientific reference
Al-Bitar, A., et al. (2025). Synchronous triple-negative breast cancer, rectal adenocarcinoma, and chemotherapy-induced hepatitis B virus reactivation: a case report and review of the literature. Journal of medical case reports, 19(1), 382
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