Overview of therapeutic strategies for hepatocellular carcinoma

In recent years, major advances have been made in the treatment of advanced hepatocellular carcinoma. However, a significant proportion of patients still show resistance to these treatments. Precision therapies are increasingly taking into account the unique molecular and cellular characteristics of each tumor to personalize treatment regimens. The aim is to improve anti-cancer efficacy while reducing the burden of side effects. To date, the use of precision therapy in hepatocellular carcinoma remains marginal. In this review, the authors present the latest data on therapeutic biomarkers, molecular classifications and the heterogeneity of the tumor microenvironment.