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Vaccine-derived poliovirus: a threat under surveillance
13 février 2025
#Poliovirus #InfectiousDiseases #Vaccine #Vaccination #nOPVS2 #Immunity #cVDPV
Circulating vaccine-derived polioviruses (cVDPVs) remain a persistent threat to public health, particularly in regions where vaccination coverage is insufficient. These viruses emerge when the attenuated strain of the oral polio vaccine (OPV) undergoes mutations after prolonged circulation within under-immunized populations. This phenomenon occurs when herd immunity is too weak to halt transmission of the vaccine-derived virus, allowing it time to evolve into a neurovirulent form capable of causing paralysis.
Circulating vaccine-derived polioviruses (cVDPVs) remain a persistent threat to public health, particularly in regions where vaccination coverage is insufficient. These viruses emerge when the attenuated strain of the oral polio vaccine (OPV) undergoes mutations after prolonged circulation within under-immunized populations. This phenomenon occurs when herd immunity is too weak to halt transmission of the vaccine-derived virus, allowing it time to evolve into a neurovirulent form capable of causing paralysis.
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Scientific reference
Namageyo-Funa, A. (2024). Update on vaccine-derived poliovirus outbreaks—worldwide, January 2023–June 2024. MMWR. Morbidity and Mortality Weekly Report, 73
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