Press review
The essentials of recent medical publications, unpacked by our newsroom into a clear, sourced digest, specialty by specialty.
InfectiologyPostnatal CMV: An Underestimated Risk for Infant Hearing!
#Cytomegalovirus #CMV #Hearing #Neurodevelopment #Prevention #Pediatrics Postnatal infection with cytomegalovirus (CMV) is a common viral disease that primarily affects infants, particularly in regions with a high prevalence of the virus. Generally considered benign in full-term, healthy newborns, the impact of postnatal CMV on auditory and neurological development remains uncertain. The main chal
OncologyShould surgery be broader?
#IBD #CrohnsDisease #Surgery #Intestine #Inflammation Crohn’s disease (CD) is a chronic inflammation of the digestive tract that progresses in flare-ups. It primarily affects the terminal ileum and colon. While drug treatments (anti-inflammatory drugs, immunosuppressants, biologics) help control the disease, 60 to 70% of patients require surgery at some point in their life. Surgery is particularly
OncologyAfter leukemia, a lifelong follow-up!
#Leukemia #ALL #AML #LongTermFollowUp #Oncology #Cancer Thanks to advances in pediatric oncology, the vast majority of children with acute leukemia are now cured. More than 90% of patients with acute lymphoblastic leukemia (ALL) and about 60 to 70% of children with acute myeloid leukemia (AML) survive thanks to progress in chemotherapy, immunotherapy, and stem cell transplantation. However, these
NeurologySepsis and memory: a link not to be forgotten!
#Leukemia #ALL #AML #Infection #Sepsis #Neurocognition #Memory Children diagnosed with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) are particularly vulnerable to infections due to aggressive treatments that weaken their immune systems. Chemotherapy and corticosteroids reduce natural defenses, while the use of central venous catheters increases the risk of bacterial and funga
HematologyIVIG: an ally against fever in ALL?
#Leukemia #ALL #cancer #oncology #pediatrics #prophylaxis #immunoglobulin #fever Acute lymphoblastic laukemia (ALL) is the most common pediatric cancer. Despite therapeutic advances, infections remain a major cause of complications and mortality. Approximately 20% of deaths related to pediatric hematologic cancer treatment are due to infections, accounting for more than half of non-disease-related
OncologyWeight at diagnosis: an ally or an obstacle?
#Leukemia #Cancer #BMI #Obesity #Malnutrition #Oncology Obesity and malnutrition in children are increasing worldwide. Recent data suggest that these factors may influence the progression of many diseases, including pediatric cancers. Among them, acute leukemia—comprising acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML)—remains the most common form. While therapeutic advances ha
OncologyALL: a constantly evolving battle
#Leukemia #ALL #Oncology #Chemotherapy #Immunotherapy #Innovation Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, accounting for 75% of childhood leukemias. It is characterized by excessive proliferation of immature cells in the bone marrow, preventing normal blood cell production and leading to fatigue, recurrent infections, and abnormal bleeding. Thanks to advances in che
Gastroenterology and HepatologySerum: a key to better treating IBD ?
#IBD #CrohnsDisease #Biomarker #Gastroenterology #Metabolomics #LipidomicsChronic inflammatory bowel diseases (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are digestive disorders affecting millions worldwide. These conditions are characterized by persistent inflammation of the digestive tract, occurring in flare-ups interspersed with periods of remission. While their exact ca
Medical GeneticsProgeria: a new therapeutic avenue?
#Progeria #PrematureAging #CRM1 #Selinexor #Senescence #TargetedTherapy Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare genetic disorder that causes premature aging. It is triggered by a mutation in the LMNA gene, leading to the abnormal production of progerin. This protein accumulates in the cell nucleus, disrupting cellular function and accelerating aging. Affected children develop severe
PneumonologyCystic Fibrosis: the era of personalized treatments
#CysticFibrosis #PrecisionMedicine #Lungs #Diagnosis #PersonalizedTherapy Cystic fibrosis is a hereditary disease caused by mutations in the CFTR gene, leading to a dysfunction in chloride ion transport. This defect results in the production of thick and sticky mucus in multiple organs, particularly the lungs and digestive system. The accumulation of mucus promotes chronic lung infections, inflamm
PneumonologyCystic Fibrosis: could the microbiome change everything?
#CysticFibrosis #Microbiome #InnovativeTherapies #Probiotics #LungInfections #PrecisionMedicine Cystic fibrosis is a severe genetic disease caused by mutations in the CFTR gene, disrupting ion transport and leading to thick mucus accumulation in the airways. Despite advances with CFTR modulators, these treatments remain inaccessible to some patients and do not completely eliminate chronic infectio
NeurologyCMT2A: Towards the End of a Therapeutic Deadlock?
#Neurology #CharcotDisease #Neuropathy #CMT2A #MFN2 Charcot-Marie-Tooth disease type 2A (CMT2A) is a rare hereditary sensorimotor neuropathy caused by mutations in the MFN2 gene. Essential for mitochondrial fusion and the proper functioning of peripheral neurons, this protein plays a key role in nerve signal transmission. Its mutation leads to an energy dysfunction in nerve cells and progressive d