2024-12-06
Blood biomarkers for tuberculosis diagnosis in HIV patients
Infectiology
Screening for Tuberculosis in HIV Patients: Can Blood Biomarkers Make a Difference?
This study analyzed 65 trials, involving more than 16,000 patients, and explored 156 blood protein biomarkers.The results indicate that blood biomarkers offer a promising alternative for TB screening among people living with HIV. For instance, C-reactive protein demonstrates a sensitivity of 93% and a specificity of 59% in this population. Similarly, markers such as IP-10, NCAM-1, and SAA also stand out. Finally, multi-biomarker signatures, which combine several proteins, show superior performance.
Despite these advances, broader clinical validation and the development of accessible point-of-care tests remain essential.
Towards a more accurate and accessible diagnosis of tuberculosis in HIV infection
Blood biomarkers represent a significant advancement for rapid and non-invasive TB screening in HIV patients. They pave the way for earlier and improved TB management, particularly in low-resource settings. However, several challenges remain, including validating these biomarkers in diverse cohorts, developing affordable point-of-care tests, and enhancing research on multi-biomarker signatures to optimize diagnostic efficiency.
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