Previous Next

2024-03-19

Efficacy and safety of enfortumab and pembrolizumab in urothelial carcinoma

Oncology

Until now, no treatment has shown superior efficacy to platinum-based chemotherapy in improving overall survival in patients with treatment-naive locally advanced or metastatic urothelial carcinoma. In this phase 3 clinical trial, investigators compared the efficacy and safety of enfortumab and pembrolizumab to platinum-based chemotherapy in 886 patients with previously untreated locally advanced or metastatic urothelial carcinoma. Progression-free survival and overall survival were longer in the enfortumab - pembrolizumab arm than in the chemotherapy arm. The median number of treatment cycles was 12 in the enfortumab - pembrolizumab arm, and 6 in the chemotherapy arm. 

Source(s) :
Thomas Powles et al. Enfortumab Vedotin and Pembrolizumab in Untreated Advanced Urothelial Cancer. N Engl J Med. 2024 Mar 7;390(10):875-888. ;

Last press reviews


Virtual reality: a weapon against stigma?

By Ana Espino | Published on september 16, 2025 | 3 min read

TyG Index: a new ally against PCOS?

By Ana Espino | Published on september 18, 2025 | 3 min read...

How our cells neutralize toxic RNAs

By Lila Rouland | Published September 16, 2025 | 3 min read<br>