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2024-01-30

Homocysteine, B Vitamins, and Autism Spectrum Disorders (ASD)

Pediatrics

Previous studies have suggested a link between serum levels of homocysteine and B vitamins and autism spectrum disorders. However, the causal relationships between these traits remained unexplored. In this study, researchers used Mendelian randomization analyses to assess causal relationships between 47 single nucleotide polymorphisms (13 related to homocysteine, 13 to vitamin B9, 14 to vitamin B6, and 7 to vitamin B12) and the risk of autism spectrum disorders. A statistical association was identified between genetically predicted serum vitamin B12 levels and the risk of autism spectrum disorder with one of the methods used, but not with the others. No causal relationship was found between the risk of autism spectrum disorder and other B vitamins or homocysteine.

Source(s) :
Tianyu Jin et al. Inferring the genetic effects of serum homocysteine and vitamin B levels on autism spectral disorder through Mendelian randomization. Eur J Nutr. 2024 Jan 24. ;

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