Previous Next

2024-03-01

SGLT-2 inhibitors in peritoneal dialysis patients

Urology-nephrology

Volume overload is associated with high mortality in peritoneal dialysis patients. This overload is incompletely corrected by diuretics, fluid restriction or icodextrin-based solutions. Alternative strategies are therefore required. In this multicenter, randomized, double-blind, placebo-controlled clinical trial, investigators are evaluating the value of SGLT-2 inhibitors for reducing volume overload in patients undergoing peritoneal dialysis. At least 36 randomized patients must be recruited. The primary endpoint is the change in daily ultrafiltration volume from baseline to week 8. Key secondary endpoints include changes in biomarkers, residual renal function and anemia-related parameters.

Source(s) :
Yohei Doi et al. Effects of sodium-glucose co-transporter 2 inhibitors on ultrafiltration in patients with peritoneal dialysis: a protocol for a randomized, double-blind, placebo-controlled, crossover trial (EMPOWERED). Clin Exp Nephrol. 2024 Feb 25. ;

Last press reviews


Virtual reality: a weapon against stigma?

By Ana Espino | Published on september 16, 2025 | 3 min read

TyG Index: a new ally against PCOS?

By Ana Espino | Published on september 18, 2025 | 3 min read...

How our cells neutralize toxic RNAs

By Lila Rouland | Published September 16, 2025 | 3 min read<br>