Migraine and gut microbiota

Gastroenterology and Hepatology

Migraine attacks are considered as neurological disease. In addition to genetic and environmental factors, gut microbiota may be involved in the onset of these attacks. Recent studies have shown that dysbiosis of gut microbiota can affect the release of neurotransmitters and inflammatory mediators. This dysbiosis could therefore increase the risk of migraine.

In this study, researchers assessed the link between gut microbiota and migraine using a Mendelian randomization approach.

The results showed that certain species present in gut microbiota, such as Lachnospiraceae, were associated with an increased risk of migraine, while other species, such as Blautia and Eubacterium, were associated with a reduced risk of migraine.

In addition, specific metabolic pathways linked to the synthesis of methionine and plasma hydrocinnamate, a metabolite influenced by Blautia and Bacteroides fragilis, were also associated with a reduced risk of migraine.

The authors conclude that certain components of gut microbiota may play a role in modulating migraine risk, underlining the importance of the gut-brain axis in migraine pathology.

This study offers new insights into potential targets for therapeutic interventions to treat or prevent migraine by modulating gut microbiota.

Source(s) :
Qu, K., Li, M., Lin, G., Cui, Z., Li, J., Yang, R., & Ming, D. (2024). To analyze the relationship between gut microbiota, metabolites and migraine: a two-sample Mendelian randomization study. Frontiers in Microbiology, 15 ;

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