2024-11-08
CAR-T PSCA Therapy: A New Hope for Castration-Resistant Prostate Cancer
Oncology
CAR-T PSCA Therapy: Results And Initial Clinical Observations
In this study, 14 patients with significant PSCA expression and advanced mCRPC were divided into three cohorts, each receiving increasing doses of PSCA CAR-T cells, with some patients undergoing prior lymphodepletion (LD):
- Cohort DL1: 100 million CAR-T cells without lymphodepletion.
- Cohort DL2: 100 million CAR-T cells with standard lymphodepletion.
- Cohort DL3: 100 million CAR-T cells with reduced lymphodepletion.
The results showed an antitumor response in 4 out of 14 patients, with a 30% reduction in prostate-specific antigen levels. Dynamic changes in the composition of peripheral blood T cells confirmed immune system activation. Radiographic improvements in some participants indicated a reduction in tumor mass. Additionally, a moderate cytokine release syndrome was observed, without severe neurological or immune toxicity. Overall, CAR-T therapy was well tolerated, with grade 3 cystitis being the most common DLT.
Toward Optimizing CAR-T Therapies in mCRPC
These findings demonstrate that CAR-T cells targeting the PSCA antigen represent a promising therapeutic approach for mCRPC. Besides inducing an effective antitumor response, the safety profile is acceptable. These results lay the groundwork for optimizing dosages and combination strategies to enhance CAR-T cell persistence. Future directions for this therapy could include adjustments in lymphodepletion, development of next-generation CAR-T cells, and exploration of additional antigen targets to maximize benefits for patients resistant to current treatments.

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