Mesenchymal stem cells, a therapeutic strategy to combat thymus aging

Mesenchymal stem cells play a crucial role in tissue regeneration and immune system modulation. They secrete bioactive factors involved in tissue repair and inflammation reduction. They are particularly important in the fight against thymus aging.

 

With age, the thymus undergoes an involution characterized by reduced lymphocyte production. This is due to a reduced number of thymic epithelial cells. 

 

In this study, aged macaques were treated with mesenchymal stem cells. The methodological approach involved administration of these mesenchymal stem cells by intravenous injection into the femoral vein. The changes induced by these cells were assessed using histological and molecular methods such as hematoxylin and eosin staining, immunofluorescence and ELISA assays.