The neuroprotective effects of metformin

The combination of lifestyle interventions and disease-modifying drugs could be an interesting approach to preventing cognitive impairment. Disease-modifying drugs are known or repurposed drugs, including metformin. A link has been established between type 2 diabetes and Alzheimer's disease, with potential neuroprotective effects of metformin. In this international, randomized, controlled, double-blind, phase 2 clinical trial, 600 participants were recruited at 3 sites for a total study duration of 2 years. Metformin is administered in the form of 500 mg tablets.