High levels of HDL cholesterol reduce the risk of developing low back pain

Low back pain affects many people and can have a variety of causes, including metabolic factors. Lipid levels, such as HDL cholesterol (HDL-C), LDL cholesterol (LDL-C) and triglycerides (TG), have been associated with various health problems, but their link with low back pain remains unclear. The aim of this study was to assess whether lipid levels directly influenced the risk of low back pain using Mendelian Randomisation (MR), a method that helps to establish causal links by minimising confounding bias and reverse causation.