Previous Next

2024-03-20

A promising new strategy for rheumatoid arthritis?

Rhumatology

The progression of rheumatoid arthritis can be accelerated by the abnormal proliferation of aggressive fibroblast-like synoviocytes and the persistence of synovial inflammation. In this study, researchers evaluated the value of a strategy acting simultaneously on these two mechanisms to restore synovial homeostasis and treat rheumatoid arthritis. They developed a soluble hyaluronic acid-based microneedle for transdermal administration of biomimetic nanocomplexes containing human serum albumin. The nanocomplexes thus administered accumulated in the joint microenvironment and acted as expected on the two mechanisms involved in the progression of rheumatoid arthritis. 

Source(s) :
Peng Hua et al. Microneedle-assisted dual delivery of PUMA gene and celastrol for synergistic therapy of rheumatoid arthritis through restoring synovial homeostasis. Bioact Mater. 2024 Mar 1:36:83-95. ;

Last press reviews


Eat without fear: anti-ige antibody omalizumab, a new weapon against food allergies

#Omalizumab #FoodAllergies #IgE #Anaphylaxis #Immunotherapy  ...

Vitamin D and tuberculosis: an overestimated protection?

By Ana Espino | Published on July 18, 2025 | 2 min read

Outdoor temperature and severe hyponatremia: a growing threat in the age of climate change

By Lila Rouland | Published on July 17, 2025 | 3 min read  ...