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Alzheimer’s: a question of genetic timing?
21 septembre 2025
By Ana Espino | Published on september 21, 2025 | 3 min read
#Alzheimer #Genetics #Neurology
Alzheimer’s disease is a progressive neurodegenerative disorder responsible for irreversible cognitive decline, linked to abnormal accumulation of amyloid and tau proteins in the brain. While early-onset familial forms are caused by rare genetic mutations, most cases are sporadic, shaped by a complex interplay of genes and environment. Among the key factors, the age at onset of first symptoms plays a central role, directly influencing clinical progression and functional prognosis.
#Alzheimer #Genetics #Neurology
Alzheimer’s disease is a progressive neurodegenerative disorder responsible for irreversible cognitive decline, linked to abnormal accumulation of amyloid and tau proteins in the brain. While early-onset familial forms are caused by rare genetic mutations, most cases are sporadic, shaped by a complex interplay of genes and environment. Among the key factors, the age at onset of first symptoms plays a central role, directly influencing clinical progression and functional prognosis.
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Scientific reference
Blue, E. E., et al. (2025). Multi-ancestry meta-analysis identifies genetic modifiers of age-at-onset of Alzheimer's disease at known and novel loci. Alzheimer's & dementia : the journal of the Alzheimer's Association, 21(9), e70489
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