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Gallstones: Genetics strikes back!
30 septembre 2025
By Ana Espino | Published on september 30, 2025 | 3 min read
#GallstoneDisease #GeneticLoci #GeneticVariants
Gallstone disease, or cholelithiasis, is an extremely common digestive condition, affecting up to 25% of adults in some populations. Although often asymptomatic, it can lead to serious complications such as acute cholecystitis, biliary pancreatitis, or chronic debilitating pain. While metabolic and environmental factors (obesity, diet, sedentary lifestyle) are well-established contributors, our understanding of genetic factors remains incomplete—despite heritability being estimated at nearly 50%.
#GallstoneDisease #GeneticLoci #GeneticVariants
Gallstone disease, or cholelithiasis, is an extremely common digestive condition, affecting up to 25% of adults in some populations. Although often asymptomatic, it can lead to serious complications such as acute cholecystitis, biliary pancreatitis, or chronic debilitating pain. While metabolic and environmental factors (obesity, diet, sedentary lifestyle) are well-established contributors, our understanding of genetic factors remains incomplete—despite heritability being estimated at nearly 50%.
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Scientific reference
Chen, H., et al. (2025). Integrative genome-wide analysis unveils the genetic landscape of gallstone disease and highlights novel loci with therapeutic potential. BMJ open gastroenterology, 12(1), e001976
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