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CDK6 inhibits de novo lipogenesis in white adipose tissue but not in the liver
20 août 2025
By Lila Rouland | Published on august 20, 2025 | 3 min read
#DeNovoLipogenesis #WhiteAdiposeTissue #Obesity #Type2Diabetes #LipidMetabolism
This study explores the role of CDK6 (Cyclin-dependent kinase 6) in regulating de novo lipogenesis (DNL)—the synthesis of fatty acids from non-lipid precursors. DNL in white adipose tissue (WAT) is linked to improved insulin sensitivity, whereas its activation in the liver promotes insulin resistance, fatty liver (steatosis), and other metabolic disorders. The goal was to determine whether targeted inhibition of CDK6 could enhance beneficial DNL in adipose tissue without worsening hepatic side effects.
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Scientific reference
Hu AJ, Li W, Dinh C, Zhang Y, Hu JK, Daniele SG, Hou X, Yang Z, Asara JM, Hu G, Farmer SR, Hu MG. Nature Communications. 2024; 15:1091.
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