This content is in French.
How our cells neutralize toxic RNAs
16 septembre 2025
By Lila Rouland | Published September 16, 2025 | 3 min read
#ModifiedRNA #ADK #ADAL #CellularToxicity #Metabolism #Purines #AMPK #MetabolicDiseases #Lysosomes #Pharmacology
RNAs undergo more than 170 post-transcriptional modifications. Their degradation generates modified nucleosides, some of which are toxic. This study identifies N6-methyladenosine (m⁶A), N6,N6-dimethyladenosine (m⁶,⁶A), and isopentenyladenosine (i⁶A) as particularly cytotoxic. A conserved metabolic mechanism involving adenosine kinase (ADK) and adenosine deaminase-like (ADAL) transforms these nucleosides into inosine monophosphate (IMP). Inactivation of this pathway leads to severe cellular toxicity, glucose intolerance, and lysosomal dysfunction.
#ModifiedRNA #ADK #ADAL #CellularToxicity #Metabolism #Purines #AMPK #MetabolicDiseases #Lysosomes #Pharmacology
RNAs undergo more than 170 post-transcriptional modifications. Their degradation generates modified nucleosides, some of which are toxic. This study identifies N6-methyladenosine (m⁶A), N6,N6-dimethyladenosine (m⁶,⁶A), and isopentenyladenosine (i⁶A) as particularly cytotoxic. A conserved metabolic mechanism involving adenosine kinase (ADK) and adenosine deaminase-like (ADAL) transforms these nucleosides into inosine monophosphate (IMP). Inactivation of this pathway leads to severe cellular toxicity, glucose intolerance, and lysosomal dysfunction.
Sign in to read the rest
Reserved for healthcare professionals, free registration.
Scientific reference
Ogawa, A., et al. (2025). Adenosine kinase and ADAL coordinate detoxification of modified adenosines to safeguard metabolism. Cell, 188(19), 1–19.
View the source
