Crohn’s Disease: targeting map for better treatment?

#CrohnsDisease #CD #MAP #vaccine #vaccination  


Crohn’s disease (CD) is a chronic inflammatory condition of the gastrointestinal tract, marked by persistent intestinal inflammation. Its etiology remains poorly understood, resulting from a complex interplay between genetic predisposition, environmental factors, immune dysregulation, and alterations of the gut microbiota. Despite therapeutic advances, the disease remains progressive, recurrent, and incurable. A significant unmet medical need persists, especially for patients with refractory disease or frequent relapses.

Among the pathogenic hypotheses being explored, the involvement of an intracellular infectious agent—particularly Mycobacterium avium subspecies paratuberculosis (MAP)—has regained interest. This mycobacterium has been detected in the intestinal tissues of some CD patients and may trigger or sustain a chronic immune response in genetically predisposed individuals.