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Severe dengue: a victim of its own defense?
8 juillet 2025
#Dengue #ImmuneResponse #Immunity #NKCells
#TCells
Dengue is an arboviral disease endemic in over 100 countries and poses a major public health threat. While most cases are mild, severe forms—severe dengue (SD) or dengue hemorrhagic fever—are marked by vascular hyperpermeability, hypovolemic shock, and a risk of death. Notably, these severe manifestations are often the result of an exacerbated immune response rather than viral replication itself.
Dengue is an arboviral disease endemic in over 100 countries and poses a major public health threat. While most cases are mild, severe forms—severe dengue (SD) or dengue hemorrhagic fever—are marked by vascular hyperpermeability, hypovolemic shock, and a risk of death. Notably, these severe manifestations are often the result of an exacerbated immune response rather than viral replication itself.
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Scientific reference
Yoo, J. S., et al. (2025). Dysregulated immune cell responses in severe dengue pathogenesis. Frontiers in immunology, 16, 1600999.
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