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Dengue: Is safe vaccination possible?
10 juillet 2025
#Dengue #Vaccine #Immunity #ADE #Virus
#Immunogenicity
Dengue is a major arboviral disease affecting millions of people each year, particularly in tropical and subtropical regions. Transmitted by Aedes mosquitoes, it can progress to severe forms, especially during secondary infections with a different viral serotype. This is partly due to a mechanism known as Antibody-Dependent Enhancement (ADE), in which non-neutralizing antibodies facilitate the virus's entry into host cells, worsening the disease.
Dengue is a major arboviral disease affecting millions of people each year, particularly in tropical and subtropical regions. Transmitted by Aedes mosquitoes, it can progress to severe forms, especially during secondary infections with a different viral serotype. This is partly due to a mechanism known as Antibody-Dependent Enhancement (ADE), in which non-neutralizing antibodies facilitate the virus's entry into host cells, worsening the disease.
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Scientific reference
Tan, B. E. K., et al. (2025). Development of New Live-Attenuated Vaccine Candidates Lacking Antibody-Dependent Enhancement (ADE) Against Dengue. Vaccines, 13(5), 532
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