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Cross-addictions: when drugs and alcohol reinforce each other

8 janvier 2026

Cross-addictions: when drugs and alcohol reinforce each other

By Ana Espino | Published on January 8, 2026 | 3 min readAlcohol and drug dependence represent a major public health issue and are frequently observed as comorbid conditions. When a substance use disorder (SUD) co-occurs with problematic alcohol consumption, clinical outcomes are more severe: increased risk of relapse, worsening of psychiatric disorders, and reduced response to treatment. One of t

By Ana Espino | Published on January 8, 2026 | 3 min read


Alcohol and drug dependence represent a major public health issue and are frequently observed as comorbid conditions. When a substance use disorder (SUD) co-occurs with problematic alcohol consumption, clinical outcomes are more severe: increased risk of relapse, worsening of psychiatric disorders, and reduced response to treatment. One of the main limitations of current approaches is that they too often consider each addiction separately, without integrating the biological, neurocognitive, and behavioral interactions between substances.  

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Scientific reference

McGinn, M. A., et al. (2021). Drug addiction co-morbidity with alcohol: Neurobiological insights. International review of neurobiology, 157, 409-472

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