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Unsung conductors of food tolerance
4 juillet 2025
#OralTolerance
#pTreg #IntestinalInflammation #LymphoidDCs #FoodAllergy
Immune tolerance to food is a cornerstone of gut health. It notably relies on peripheral regulatory T cells (pTreg), which prevent inappropriate reactions to food proteins. But who educates these cells? A U.S. research team has highlighted the crucial role of a rare subtype of dendritic cells expressing RORγt. Their absence may well explain certain forms of food allergy.
The study published in Cell shows that these cells, derived from the lymphoid lineage, are the true conductors of oral tolerance—far more than type 3 innate lymphoid cells (ILC3), previously suspected.
Immune tolerance to food is a cornerstone of gut health. It notably relies on peripheral regulatory T cells (pTreg), which prevent inappropriate reactions to food proteins. But who educates these cells? A U.S. research team has highlighted the crucial role of a rare subtype of dendritic cells expressing RORγt. Their absence may well explain certain forms of food allergy.
The study published in Cell shows that these cells, derived from the lymphoid lineage, are the true conductors of oral tolerance—far more than type 3 innate lymphoid cells (ILC3), previously suspected.
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Scientific reference
Rodrigues, P. F., et al. (2025). Rorgt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens. Cell, 188(10), 2720–2737.
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