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Nanoparticles to deliver a pancreatic cancer drug
3 avril 2024
Researchers here have synthesized a prodrug, squalenoyl-chidamide, binding lipophilic squalene to the hydrophilic antitumor drug chidamide via trypsin-sensitive binding. The nanoparticles developed showed significantly higher in…
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Scientific reference
Junyan Chen et al. Integration of caveolin-mediated cytosolic delivery and enzyme-responsive releasing of squalenoyl nanoparticles enhance the anti-cancer efficacy of chidamide in pancreatic cancer. Int J Pharm. 2024 Mar 30:124072
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