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Epilepsy: targeting the right mechanism to treat better?
12 février 2026
By Ana Espino | Published on February 12, 2026 | 3 min readEpilepsy is a chronic neurological disorder characterized by abnormal electrical activity in the brain, leading to seizures that are often sudden and disabling. While the majority of patients respond to antiseizure medications, approximately 30% develop drug‑resistant epilepsy, defined by the failure of at least two appropriately chosen an
By Ana Espino | Published on February 12, 2026 | 3 min read
Epilepsy is a chronic neurological disorder characterized by abnormal electrical activity in the brain, leading to seizures that are often sudden and disabling. While the majority of patients respond to antiseizure medications, approximately 30% develop drug‑resistant epilepsy, defined by the failure of at least two appropriately chosen and well‑tolerated treatments. This refractory form is associated with a major deterioration in quality of life, an increased risk of psychiatric comorbidities, and premature mortality, notably due to SUDEP (sudden unexpected death in epilepsy).
Epilepsy is a chronic neurological disorder characterized by abnormal electrical activity in the brain, leading to seizures that are often sudden and disabling. While the majority of patients respond to antiseizure medications, approximately 30% develop drug‑resistant epilepsy, defined by the failure of at least two appropriately chosen and well‑tolerated treatments. This refractory form is associated with a major deterioration in quality of life, an increased risk of psychiatric comorbidities, and premature mortality, notably due to SUDEP (sudden unexpected death in epilepsy).
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Scientific reference
Auvin S. Targeted therapies in epilepsies. Rev Neurol (Paris). 2025 May;181(5):450-455
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